Background. Acne is a dermatosis that involves an altered sebum pattern. Objectives. (1) To evaluate if a treatment based on\r\nantibiotics (lymecycline) can alter fatty acids contents of the sebum of patients with acne; (2) to evaluate if oral supplementation of\r\nfatty acids can interfere with fatty acids contents of the sebum of patients with acne; (3) to evaluate if there is any interaction in fatty\r\nacids contents of the sebum of patients with acne when they use both antibiotics and oral supplementation of fatty acids. Methods.\r\nForty-five male volunteers with inflammatory acne vulgaris were treated with 300mg of lymecycline per day, with 540mg of ??-\r\nlinolenic acid, 1,200mg of linoleic acid, and 510mg of oleic acid per day, or with both regimens for 90 days. Every 30 days, a sample\r\nof sebum from the forehead was collected for fatty acids� chromatographic analysis. Results. Twelve fatty acids studied exhibited\r\nsome kind of pattern changes during the study: C12:0, C14:0, C15:0, C16:1, C18:0, C18:1n9c+C18:1n9t, C18:2n6t, C18:3n6, C18:3n3,\r\nC20:1, C22:0, and C24:0. Conclusions. The daily administration of lymecycline and/or specific fatty acids may slightly influence\r\nsome fatty acids levels present in the sebum of patients with inflammatory acne vulgaris.
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